Novel monoclonal antibodies against Pdx1 reveal feedback regulation of Pdx1 protein levels
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چکیده
منابع مشابه
Novel monoclonal antibodies against Pdx1 reveal feedback regulation of Pdx1 protein levels
The aim of this study was to characterize two monoclonal antibodies (F6A11 and F109-D12) generated against Pdx1 (pancreatic and duodenal homeobox-1), a homeodomain transcription factor, which is critical for pancreas formation as well as for normal pancreatic beta cell function. For production of monoclonal antibodies, we immunized Robertsonian POSF (RBF)mice with a GST-Pdx1 fusion protein cont...
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Marc Nicolino*, Kathryn C. Claiborn*, Valérie Senée , Anne Boland , Doris A. Stoffers , Cécile Julier 4,5 1 Hôpital Femme-Mère-Enfant, Division of Pediatric Endocrinology, Lyon University, Lyon, France 2 INSERM U870, CIC, Lyon, France. Department of Medicine, Division of Endocrinology, Diabetes, and Metabolism and the Institute for Diabetes, Obesity and Metabolism, University of Pennsylvania Sc...
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ژورنال
عنوان ژورنال: European Journal of Histochemistry
سال: 2010
ISSN: 2038-8306,1121-760X
DOI: 10.4081/ejh.2010.e19